News and Research





Buffalo, N.Y.- Garwood Medical Devices, LLC, a company advancing infection control through innovation, announced today their collaboration with ANSYS through the ANSYS Startup Program. This collaboration will allow Garwood Medical Devices to speed development time of products and allow the company to perform accurate and virtual tests of their concepts.




Garwood Medical Devices Announces Strategic Hire to Facilitate Engineering for Advanced Medical Devices

New addition brings engineering design and commercialization experience with multiple regulated medical products

Buffalo, N.Y.- Garwood Medical Devices, LLC. a company advancing infection control through innovation, announced today the appointment of Brian Peterson as the Company’s Vice President and Chief Technology Officer. Hired for his expertise in the design and development of various types of medical products, Mr. Peterson will be tasked with driving Garwood’s engineering and technology platforms for the company’s advanced medical products.




Engineers receive $1 million for implantable system to detect lung cancer

Collaborators include Intel, Garwood Medical Devices and Roswell Park Cancer Institute




Garwood Medical's two-pronged strategy coming into focus

by Dan Miner, Buffalo Business First

Garwood Medical Devices leaders say they're making steady progress on two separate medical device products, expecting to launch them both in 2018.




Techconnect World Innovation Conference: May 2017

Computational Analysis of Electrical Stimulation Devices to Promote Wound Healing

Electric stimulation (ES) therapy involves the use of lower energy, static, or time-varying electric and magnetic fields and associated electrical currents to stimulate a therapeutic physiological response that accelerates wound healing in human tissue. In this presentation, we discuss this therapy and demonstrate the use of 3D computational models to predict the electric field and current density patterns induced in human tissue by voltage activated electrodes on the skin surface. The analysis takes into account electrode configurations, transient voltage waveforms and all relevant tissues including their frequency dependent electrical properties. The models provide insight into ES therapy and enable the rational design of novel ES devices.




Garwood Medical Devices Announces Two Key Patents Granted

For immediate release: March 31, 2017

BUFFALO, NY – Garwood Medical Devices, a Western New York medical device company whose
mission is advancing infection control through innovation, announced today that the U.S. Patent
and Trademark Office has granted two important patents to the company.




Bacterial Biofilms on Electrochemically Active Cathodic Titanium Surfaces

Jin Guo

Bacterial infection is a major concern in orthopedic implants that may lead to implant failure and revision. The resistance of bacterial biofilms to antibiotics increases the difficulties of fighting against infections. In this work, the effects of electrochemical reduction reactions on bacterial biofilm cultured on electrochemically active metal surfaces were investigated to better understand the mechanism of bacterial response to reduction electrochemistry. The influence of voltage and electrolyte were studied on the cellular behavior of E. coli HM22 cultured on commercially pure titanium (cpTi) surfaces held at cathodic voltages. Relatively weak potentials at -1 V (vs. Ag/AgCl) could significantly reduce the cell viability in saline solution after 24 hours compared to controls at open circuit potential (OCP, in the range of -0.2 V to -0.38 V vs. Ag/AgCl) (p < 0.05). However, bacterial biofilms cultured on cpTi surfaces in LB media require more negative voltage (below -1.2 V) to induce significant killing efficacy. On the other hand, the cellular response was correlated with the electrochemical properties of titanium-oxide-solution interface through methods like electrochemical impedance spectroscopy (EIS) and current density monitoring. The electrochemical impedance of the oxide-bacteriasolution interface was dependent on the presence of applied voltage. Sustained voltage treatment at -1 V decreased the impedance of titanium-oxide-bacteria interface in both LB media and NaCl solution at 0.1 Hz than those at OCP (p<0.05). In LB media, the presence of bacterial biofilm significantly reduced the average current density experienced by cpTi surfaces at -1 V compared to controls without cells at -1 V in 24 hours (p < 0.05). Significant morphological changes were found after voltage treatment in NaCl solution and LB media. In general, ruptured cells after voltage treatment at -1 V in NaCl solution ended in less length, width and height than control cells at OCP (p<0.05). The applied potential at -1 V decreased the length and height of all the cells in LB media after time-lapse photography compared to those of untreated controls (p<0.05). Finally, time-lapse photography, which could assess cellular movement of bacteria under voltage treatment in real time, was utilized and proved to be an effective method of cellular investigation besides LIVE/DEAD assay, scanning electron microscope (SEM) and atomic force microscopy (AFM). Average bacterial cell velocity significantly increased once -1 V voltage treatment started and then dropped in two hours in NaCl solution (p<0.05), while no such difference was seen during the test in LB media.




Cathodic voltage-controlled electrical stimulation of titanium for prevention of methicillin-resistant Staphylococcus aureus and Acinetobacter baumannii biofilm infections

Mary Canty a, Nicole Luke-Marshall b, Anthony Campagnari b, Mark Ehrensberger a,c,⇑

Antibiotic resistance of bacterial biofilms limits available treatment methods for implant-associated orthopaedic infections. This study evaluated the effects of applying cathodic voltage-controlled electrical stimulations (CVCES) of 1.5 V and 1.8 V (vs. Ag/AgCl) to coupons of commercially pure titanium (cpTi) incubated in cultures of methicillin-resistant Staphylococcus aureus (MRSA) and Acinetobacter baumannii (A. baumannii) as a method of preventing bacterial attachment. Stimulations were applied for 2, 4, and 8 h and coupon-associated and planktonic colony-forming units (CFU) were enumerated following stimulation. Compared to open circuit potential (OCP) controls, CVCES for 4 h at 1.8 V significantly reduced 4 7 coupon-associated MRSA CFU by 99.9% (1.30  107 vs. 4.45  10 , p = 0.047) and A. baumannii coupon4 associated CFU by 99.9% (1.64  10 vs. 5.93  10 , p = 0.001) and reduced planktonic CFU below detectable levels for both strains. CVCES at 1.8 V for 8 h also reduced coupon-associated and planktonic CFU below detectable levels for each strain. CVCES at 1.5 V for 4 and 8 h, and 1.8 V for 2 h did not result in clinically relevant reductions. For 4 and 8 h stimulations, the current density was significantly higher for 1.8 V than 1.5 V, an effect directly related to the rate of water and oxygen reduction on the cpTi surface. This significantly increased the pH, a suspected influence in decreased CFU viability. The voltagedependent electrochemical properties of cpTi likely contribute to the observed antimicrobial effects of CVCES. This study revealed that CVCES of titanium could prevent coupon-associated and planktonic CFU of Gram-positive MRSA and Gram-negative A. baumannii from reaching detectable levels in a magnitude-dependent and time-dependent manner.




Buffalo startup exec on the complexity of finding a manufacturing partner

Dan Miner, Buffalo Business First

This week's cover story in Buffalo Business First focuses on the growing cohort of startup companies moving into manufacturing – an obvious step for any enterprise that plans to have a physical product.





New cosurface capacitive stimulators for the development of active osseointegrative implantable devices

Marco P. Soares dos Santos1,2,* , Ana Marote3,* , T. Santos4, JoãoTorrão2, A. Ramos1,2, JoséA. O. Simões2, OdeteA. B. daCruz e Silva3, Edward P. Furlani5,6, Sandra I.Vieira3,† & JorgeA. F. Ferreira1,2,†

Non-drug strategies based on biophysical stimulation have been emphasized for the treatment and prevention of musculoskeletal conditions. However, to date, an effective stimulation system for intracorporeal therapies has not been proposed. This is particularly true for active intramedullary implants that aim to optimize osseointegration. The increasing demand for these implants, particularly for hip and knee replacements, has driven the design of innovative stimulation systems that are effective in bone-implant integration. In this paper, a new cosurface-based capacitive system concept is proposed for the design of implantable devices that deliver controllable and personalized electric field stimuli to target tissues. A prototype architecture of this system was constructed for in vitro tests, and its ability to deliver controllable stimuli was numerically analyzed. Successful results were obtained for osteoblastic proliferation and differentiation in the in vitro tests. This work provides, for the first time, a design of a stimulation system that can be embedded in active implantable devices for controllable bone-implant integration and regeneration. The proposed cosurface design holds potential for the implementation of novel and innovative personalized stimulatory therapies based on the delivery of electric fields to bone cells.