News and Research




Chronic Wound Biofilm Model

Kasturi Ganesh, Mithun Sinha, Shomita S. Mathew-Steiner, Amitava Das, Sashwati Roy, and Chandan K. Sen

Significance: Multispecies microbial biofilms may contribute to wound chronicity by derailing the inherent reparative process of the host tissue. In the biofilm form, bacteria are encased within an extracellular polymeric substance and become recalcitrant to antimicrobials and host defenses. For biofilms of relevance to human health, there are two primary contributing factors: the microbial species involved and host response which, in turn, shapes microbial processes over time. This progressive interaction between microbial species and the host is an iterative process that helps evolve an acute-phase infection to a pathogenic chronic biofilm. Thus, long-term wound infection studies are needed to understand the longitudinal cascade of events that culminate into a pathogenic wound biofilm.

Recent Advances: Our laboratory has recently published the first long-term (2 month) study of polymicrobial wound biofilm infection in a translationally valuable porcine wound model.

Critical Issues: It is widely recognized that the porcine system represents the most translationally valuable approach to experimentally model human skin wounds. A meaningful experimental biofilm model must be in vivo, include mixed species of clinically relevant microbes, and be studied longitudinally long term. Cross-validation of such experimental findings with findings from biofilm-infected patient wounds is critically important. 

Future Directions: Additional value may be added to the experimental system described above by studying pigs with underlying health complications (e.g., metabolic syndrome), as is typically seen in patient populations. Full Article >>




A UB spinoff and a UB licensee selected to present at the University Startups Demo Day in Washington

Julie Molenda, UB

BUFFALO, N.Y. — University at Buffalo spinoff ZOETIC Pharmaceuticals and UB technology licensee Garwood Medical Devices are among the first 18 companies nationwide selected to present at the prestigious University Startups Demo Day. Full Article>>




UB Team travels to DC for prestigious Startup Demo Day

Charlotte Hsu, UB

Six UB staff and faculty members traveled to Washington, D.C., last week to represent the institution at the first University Startups Demo Day, a celebration of the best such companies in the nation. Full Article >>




How Norm Murray became an investor in a Buffalo biotech company

Dan Minor, Business First Reporter

The former owner of U-C Coatings Corp. – who sold the business in 2013 – got interested in backing a Buffalo biomedical startup through a connection at the Thursday Club. Full Article>>




Garwood Medical Devices closes in on $3.6 million funding goal

Dan Minor, Business First Reporter

Garwood Medical Devices is closing in on a $3.6 million Series A round from private investors in Buffalo's business and medical communities. Full Article >>




Medical device startup to hire 40 through Buffalo genomic research program

Stephen T. Watson, Buffalo News Reporter

A Buffalo medical device startup intends to create 40 jobs over five years through a partnership with a University at Buffalo genomic research program, the university announced Thursday. Full Article >>




Garwood Medical Device contracts with UB institute; pledges to create 40 jobs

Dan Minor, Business First Reporter